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Author Response: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research Author Response: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

February 2024

This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

research Mitochondrial dysfunction in an animal model of diabetic neuropathy is associated with a reduction of neurosteroid synthesis.

1 citations , March 2018 in “F1000Research”

This study found that diazepam has an exaggerated effect on GABAergic inhibitory tone in diabetic neuropathy mouse models, likely due to upregulated neurosteroidogenic enzymes responding to mitochondrial dysfunction.

research Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation

82 citations , July 2011 in “Journal of Neuroscience”

In this study, ethanol was found to enhance GABAergic neurosteroid production and inhibit long-term potentiation in rat hippocampal slices via unblocked NMDA receptor activation, effects reversible by specific inhibitors.

research Plasticity of GABAergic Inhibition

January 2014 in “eScholarship (California Digital Library)”

This article discusses the plasticity of δ-GABAARs during altered neurosteroid production and its effects on neuronal network function, with potential therapeutic strategies proposed for several neurological and psychiatric disorders.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress)

in Progress Pictures 35 upvotes 1 year ago

A 22-year-old resumed using finasteride, minoxidil, and a 0.5mm dermaroller after stopping for two years, experiencing positive results and improved mood. The discussion includes debates on the effects of finasteride on neurosteroids and the optimal dermaroller needle length for hair regrowth.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community risks with finasteride and dutasteride

138 upvotes 1 year ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

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