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Realizing the Therapeutic Potential of Neuroactive Steroid Modulators of the GABAA Receptor

research Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

40 citations , December 2019 in “Neurobiology of Stress”

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

research Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

60 citations , December 2013 in “PLoS ONE”

The researchers found that inhibiting soluble epoxide hydrolase, either genetically or pharmacologically, delayed the onset of chemically induced seizures related to GABA antagonism in experimental models.

research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol

34 citations , June 2011 in “Alcoholism: Clinical and Experimental Research”

This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.

research Nucleus‐specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus

November 2019 in “Synapse”

This study found that the 5α-reductase inhibitor finasteride affected phasic and tonic GABA A receptor-mediated currents differently in the thalamic reticular and ventrobasal nuclei of mice, suggesting endogenous neurosteroid modulation of these receptors.

research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

18 citations , September 2021 in “Journal of Neuroendocrinology”

This review discusses how neurosteroids acting on GABAA receptors may influence behavior and explores the potential for developing selective modulators for treating psychiatric disorders, but reports no new clinical results.

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community Do it yourself topical Fin and Min solution works

in Progress Pictures 119 upvotes 1 year ago

A homemade topical solution of finasteride and minoxidil effectively stopped hair shedding and promoted regrowth without side effects. Users shared experiences and discussed different concentrations and application methods.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community Do 'do it yourself' topical fin really work?

in Treatment 1 upvotes 1 year ago

DIY topical finasteride mixed with minoxidil is used due to the unavailability of pharmacy-grade options in Sweden. The user reports positive results after three months, with improved hair growth at the temples and vertex.

community I quit Oral Finasterise over a year ago and here's what I've found

in Finasteride/Dutasteride 52 upvotes 9 months ago

The user quit oral finasteride over a year ago, experienced improvements in brain fog and erectile dysfunction after quitting smoking and porn, and plans to try dutasteride. Another user shared their experience with finasteride, mentioning panic attacks and anxiety, and managed symptoms through lifestyle changes like meditation and exercise.

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