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research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth

101 citations , March 2019 in “Cell Stem Cell”

This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.

research 307 Dermatologic toxicities associated with chronic gamma-secretase inhibitor treatment for desmoid tumor

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reports that 71% of patients treated with the gamma-secretase inhibitor PF-03084014 for desmoid tumors experienced dermatologic side effects, such as follicular lesions and pruritic eruptions, which were managed with topical or systemic treatments.

Follicular Neutrophilic Inflammation in Hidradenitis Suppurativa

research Follicular Neutrophilic Inflammation (Hidradenitis Suppurativa)

January 2018 in “Springer eBooks”

Hidradenitis Suppurativa is likely an autoinflammatory disease, and better understanding its causes could improve treatments.

research Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs

34 citations , August 2016 in “Scientific Reports”

This study validated a protocol for inducing surface ectoderm differentiation from human induced pluripotent stem cells and highlighted the role of TGFβ signaling pathways in this process.

research An accessible pharmacodynamic transcriptional biomarker for notch target engagement

4 citations , February 2016 in “Clinical Pharmacology & Therapeutics”

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

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Community Join

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community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

in Research/Science 117 upvotes 2 years ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community Did somebody of you start to go in the gym during your hairloss fight?

29 upvotes 2 years ago

A 19-year-old paused weightlifting due to hair loss concerns, using finasteride to improve hair condition. Others advised continuing gym workouts while using finasteride, as it doesn't harm hair, and emphasized focusing on fitness and confidence.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 2 years ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Finasteride success for androgenic alopecia by a 27M physician (NO PICTURES)

4 upvotes 10 years ago

A 27-year-old male physician improved hair density using minoxidil 5% foam and finasteride 1mg every other day, with initial sexual side effects that subsided. He recommends trying finasteride for a year but warns against dutasteride due to potential liver effects.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Setipiprant

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