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research A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy

15 citations , July 2022 in “Nano Research”

This study suggests that using cholesterol-free liposomes, specifically PPD-Lip, as a delivery system with dutasteride may enhance the treatment of androgenetic alopecia by promoting hair regrowth in mice models.

research Cholesterol and Phospholipid-free Multilamellar Niosomes Regulate Transdermal Permeation of a Hydrophobic Agent Potentially Administrated for Treating Diseases in Deep Hair Follicles

14 citations , August 2021 in “Journal of Pharmaceutical Sciences”

This study found that cholesterol- and phospholipid-free multilamellar niosomes improved skin deposition and targeted deeper hair follicles better than hydrophobic PLGA nanoparticles for transdermal drug delivery.

Localization and Regulation of Cholesterol Transporters in the Human Hair Follicle: Mapping Changes Across the Hair Cycle

research Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle

13 citations , January 2021 in “Histochemistry and Cell Biology”

In this study, human hair follicles showed varying expression of cholesterol transport proteins during the hair cycle, suggesting a potential role of cholesterol in hair growth and cycling.

research Free internal lipids in hair from pre‐ and post‐menopausal women

7 citations , March 2005 in “International Journal of Cosmetic Science”

This study found that menopause alters hair lipids and reduces hair quality, with hormone replacement therapy mitigating some changes.

Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

research Re: Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

July 2012 in “The Journal of Urology”

This abstract reviews testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production and reports no new research findings.

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community What happens to the excess testosterone after using dut?

in Finasteride/Dutasteride 23 upvotes 1 year ago

Using dutasteride or finasteride can increase free testosterone, which may convert to estradiol, potentially causing side effects like increased estrogen levels. Individual responses vary, and some users report changes in cholesterol, hair texture, and side effects like gyno or increased sex drive.

community The case for 5ARI-free hair transplants: Dr. Zarev, Pittella, Sethi, Miln, and future treatments in development

13 upvotes 10 months ago

Some individuals experience side effects from 5AR inhibitors like finasteride and are considering hair transplants without these medications, with some opting for surgeons like Dr. Zarev. Others are exploring alternative treatments and waiting for new medications in development, while some discuss managing side effects through lifestyle changes or additional medications.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community My (30 M) blood test results after being on fin/dut for 3 years

in Finasteride/Dutasteride 19 upvotes 10 months ago

A 30-year-old male has been on finasteride/dutasteride for 3 years, with stable but still receding hairline, and blood tests showing high total testosterone but normal DHT and free testosterone levels. Despite challenges in gaining muscle, he maintains a good physique with a consistent lifting routine and recently improved results with creatine.

community Has anyone tried pumpkin seed oil for hair loss?

5 upvotes 1 year ago

Pumpkin seed oil may reduce hair loss, but its effectiveness varies. Some users combine it with medications like finasteride, minoxidil, and RU58841 for better results.

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