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research A Homozygous Frameshift Mutation in theHOXC13Gene Underlies Pure Hair and Nail Ectodermal Dysplasia in a Syrian Family

30 citations , January 2013 in “Human Mutation”

This study identified a homozygous frameshift mutation in the HOXC13 gene associated with pure hair and nail ectodermal dysplasia in a consanguineous Syrian family, suggesting crucial roles for HOXC13 in hair and nail development.

research Localized Autosomal Recessive Hypotrichosis Due to a Frameshift Mutation in the Desmoglein 4 Gene Exhibits Extensive Phenotypic Variability within a Pakistani Family

25 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The researchers identified a specific mutation in the desmoglein 4 gene linked to localized autosomal recessive hypotrichosis, which presents with variable hair loss severity in affected individuals from a large Pakistani family.

research A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population

21 citations , March 2015 in “Neurological Sciences”

This study reports that a novel frameshift mutation in the HTRA1 gene in a CARASIL pedigree led to reduced HTRA1 protein and increased TGF-β1 expression, potentially causing severe CARASIL and peripheral small arterial disease.

A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions

research A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions

10 citations , March 2019 in “Human Genetics”

This study identified a genetic variant in the SGK3 gene related to hairlessness in Scottish Deerhounds, suggesting a similar role for androgen-independent hair loss in humans.

research A new heterozygous frameshift variant in keratin 10 resulting in ichthyosis hystrix in a father and daughter

March 2023 in “JAAD case reports”

This article reviews the genetic foundations of keratins in maintaining epithelial tissue integrity and links specific keratin variants to diverse ichthyosis forms, without presenting new clinical findings.

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Community Join

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community It’s obviously not as good as having hair, but SMP is a great last option for those going through hair loss. It at least frames my face and I don’t have to worry about having the dreaded horseshoe look. Just do your research on an artist and get a natural look!

in SMP 155 upvotes 5 months ago

Scalp micropigmentation (SMP) is a viable option for those experiencing hair loss, providing a natural look similar to a buzzcut. It requires touch-ups every 3-5 years, and using products like zero shine can help manage appearance issues in different lighting.

community Why didn’t Justin Bieber boof his finasteride

727 upvotes 10 months ago

Justin Bieber's hair loss and his choice not to use finasteride or other treatments like rectal injection are discussed, with reasons speculated to be side effects or lack of concern. The conversation also mentions his past hair transplant and suggests his wealth and fame might make appearance less of a priority.

community Do I look good bald? It is late for me for min+fin. Is it a must for me to get a wig to be attractive?

in Shaved/buzzed 554 upvotes 1 year ago

The user looks good bald and could enhance their appearance by gaining muscle and growing facial hair. Some suggest trying minoxidil and finasteride, while others recommend embracing baldness and focusing on confidence.

community Even Sir David Beckham uses wig/ hair fibers. this is news to me.

in Chat 83 upvotes 1 month ago

David Beckham uses hair fibers or a wig, possibly due to exhaustion of other hair loss treatments like transplants, Minoxidil, and finasteride. Despite access to top treatments, maintaining the appearance of good hair is challenging, and some suggest he should embrace baldness.

community Is PP405 gonna flop or what???

5 months ago

PP405 is viewed skeptically, with some seeing it as overhyped and potentially ineffective compared to existing treatments like minoxidil and finasteride. While it shows some promise in activating dormant hair follicles, many believe it won't replace hair transplants or significantly outperform current options.

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