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Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations , May 2012 in “PloS one”

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

research FOXN1 Italian Founder Mutation in Indian Family: Implications in Prenatal Diagnosis

17 citations , June 2017 in “Gene”

A rare genetic mutation found in an Indian family can be detected through prenatal screening.

research Human Clinical Phenotype Associated With FOXN1 Mutations

22 citations , January 2009 in “Advances in experimental medicine and biology”

FOXN1 mutations cause severe immunodeficiency, hair loss, nail issues, and thymus defects.

research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies

9 citations , March 2015 in “International reviews of immunology”

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.

research Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations

30 citations , January 2021 in “Journal of Clinical Immunology”

FOXN1 mutations can cause varying immune and physical issues, with severity influenced by gene activity and possibly other factors.

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community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)

MagicBold in Treatments 309 upvotes 1 year ago

The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.

community Stop expecting results in 2 months!

in Treatment 125 upvotes 1 year ago

People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 1 year ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 446 upvotes 3 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

in Progress Pictures 193 upvotes 1 year ago

A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

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