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This study highlights the significance of the hf pathway for the skin permeation of ionized and hydrophilic high molecular compounds, and the usefulness of hf-plugging in evaluating their skin permeability.

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

In this study, researchers found that barrier-enhancing formulations significantly reduced the penetration of proteins into hair follicles in porcine skin models, with effectiveness varying by formulation.

This study found that hydrolyzed wheat proteins extensively penetrated both untreated and chemically treated hair, primarily occupying areas like the endocuticle and cortex.

This study found that hair follicle-plugging reduced skin permeation of certain model drugs, with effects varying based on EtOH pretreatment and the drug being evaluated.