This study found that local heterologous leukocyte-rich platelet-rich plasma improved distal skin flap viability in rats by reducing necrosis compared to the control group.
8 citations
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October 2019 in “The Journal of surgical research/Journal of surgical research” This study demonstrated that sodium valproate accelerates skin healing and reduces necrosis in a rat model of skin flap potentially through mechanisms involving GABA and histone deacetylase pathways.
6 citations
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September 2012 in “Aesthetic Plastic Surgery” This study found that prolonged topical application of minoxidil significantly increased skin flap survival in rats by promoting angiogenesis compared to shorter application or a saline control.
1 citations
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January 2019 in “Advances in Medical Sciences” This study found that a combination of azelaic acid, minoxidil, and caffeine significantly reduced skin flap necrosis in rats, likely by increasing nitric oxide content and iNOS expression, compared to individual treatments.
12 citations
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August 2015 in “Plastic Surgery” This study found that botulinum toxin type A significantly reduced skin flap necrosis in rats exposed to cigarette smoke, suggesting it may help improve flap viability in smokers.