8 citations
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February 2010 in “Journal of Dermatology” This study observed that a topical liposome formulation of a 5‐α‐reductase inhibitor effectively reduced the size of treated sebaceous glands and induced apoptosis in a hamster model, suggesting potential benefits for acne treatment.
8 citations
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May 1996 in “Endocrinology” This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.
26 citations
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January 1987 in “Archives of Dermatology” In this study, topical minoxidil did not show an antiandrogenic effect on androgen-dependent cutaneous structures in the golden Syrian hamster, suggesting it likely does not have this role in humans either.
37 citations
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November 1995 in “Journal of Investigative Dermatology” This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.
6 citations
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May 1997 in “Journal of Dermatological Science” This study found that a gene from hamster flank organs is indirectly regulated by androgens, despite lacking direct androgen responsive elements, indicating involvement of androgen-dependent transcription factors.