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      Five-Alpha-Reductase Inhibitors for Prostate Cancer Prevention

      research Five-alpha-reductase Inhibitors for prostate cancer prevention.

      37 citations , April 2008 in “The Cochrane library”
      This study concluded that five-alpha-reductase inhibitors may reduce prostate cancer risk but could increase the risk of high-grade prostate cancer in men regularly screened for the disease.
      The Clinical Applications of Five-Alpha Reductase Inhibitors

      research The clinical applications of five-alpha reductase inhibitors.

      2 citations , April 2021 in “Canadian Journal of Urology”
      This review summarizes existing studies on 5-alpha reductase inhibitors, noting their effectiveness in reducing prostate volume and cancer risk but highlighting an increased risk of higher grade prostate cancer.
      What Do We Know About 5-Alpha Reductase Inhibitors?

      research What do we know about 5-alpha reductase inhibitors?

      January 2018 in “Surgical and Cosmetic Dermatology”
      This review provides an up-to-date analysis of the efficacy and safety of five-alpha reductase inhibitors, specifically finasteride and dutasteride, for treating benign prostatic hyperplasia and male androgenetic alopecia, highlighting their FDA approval history and current use.
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    Community Join

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      community Was scared to try fin and jumped straight to 2.5mg Dut?

       36 upvotes 1 week ago
      The user started with oral minoxidil and switched to 2.5mg dutasteride, experiencing significant hair growth without side effects. They believe dutasteride has fewer side effects than finasteride due to its action on both type 1 and 2 5-alpha reductase enzymes.

      community Has there been any update or progress on the 3-alpha hydroxysteroid dehydrogenase hypothesis?

       13 upvotes 2 months ago
      The conversation discusses the hypothesis that a lack of the enzyme 3-alpha hydroxysteroid dehydrogenase (3α-HSD) on the scalp may contribute to hair loss by allowing DHT to accumulate. Despite interest in this theory, no recent research has been conducted, and current treatments like finasteride and minoxidil remain the most supported options.

      community M30, month 5 of dutasteride and minoxidil

      in Progress Pictures  250 upvotes 11 months ago
      A 30-year-old male experienced significant hair regrowth after five months of using topical minoxidil (5% foam) and oral dutasteride (0.5 mg daily). The user reported no side effects and was grateful for the progress, despite the rapid gains slowing down.

      community 5 months difference. Thoughts?

      in Is this regrowth?  84 upvotes 1 year ago
      The user has been using topical minoxidil and finasteride since January and added topical dutasteride last month, seeing significant hair regrowth in five months. Other users shared their experiences with similar treatments, discussed side effects, and asked for details about the user's routine.
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    Learn

    4 / 801 results

      learn Fluridil

      a topical anti-androgen with less systemic involvement
      • How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

      learn Cyproterone

      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects
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