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Glossary Nail Changes

alterations in nail appearance or texture indicating health issues

Nail changes refer to alterations in the appearance, texture, or growth of fingernails or toenails, which can be indicative of various health conditions. These changes can include discoloration, thickening, brittleness, pitting, or separation from the nail bed, and may be associated with systemic diseases, nutritional deficiencies, infections, or trauma. For instance, yellowing of the nails might suggest a fungal infection, while pitting could be a sign of psoriasis.

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research Lead and Calcium in Human Males Using Finger Nails and Scalp Hair

1 citations , January 2013 in “International Journal of Physical and Social Sciences”

This study found a negative correlation between lead and calcium levels in the scalp hair and finger nails of exposed and unexposed males, with variations suggesting these tissues can reflect metabolic changes over time.

research The histopathologic spectrum of psoriasis

111 citations , November 2007 in “Clinics in Dermatology”

This article discusses the histologic features of psoriasis, including psoriasiform epidermal hyperplasia and neutrophilic involvement, but reports no new clinical findings.

research LP-058 The involvement of scalp and nails in cutaneous lupus erythematosus patients: a retrospective study

July 2023

This study found significant correlations between scalp and nail involvement and laboratory findings in Korean patients with chronic cutaneous lupus erythematosus, highlighting their importance for diagnosis and management.

Examining the Acceptability of Providing Hair or Fingernail Samples as a Biomarker of Physiological Stress Among Older Adolescents

research Examining the acceptability of providing hair or fingernail samples as a biomarker of physiological stress among older adolescents.

April 2026 in “PsyArXiv (OSF Preprints)”

This study found that among young adults, willingness to provide hair and fingernail samples for cortisol measurement was similar, with discomfort around sampling as the main barrier; informational videos did not significantly alter participant willingness.

research Videodermoscopy of the hyponychium in nail bed psoriasis

76 citations , March 2008 in “Journal of the American Academy of Dermatology”

This study found that videodermoscopy can help diagnose nailbed psoriasis by revealing distinctive hyponychial capillary patterns, which correlated with disease severity and response to treatment.

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community Don't give up on finasteride folks

284 upvotes 1 year ago

Finasteride may take over two years to show results and can cause side effects like sexual dysfunction and emotional changes. Alternatives such as dutasteride and minoxidil are discussed, with varying effectiveness and side effects.

community Arthritis drug restores 100% hair on 1 in 5 alopecia patients in global trial

150 upvotes 1 week ago

An arthritis drug, Rinvoq, restores hair in some alopecia areata patients but is not effective for androgenetic alopecia. It is used for autoimmune-related skin disorders, but its high cost and lack of insurance coverage are issues.

community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

168 upvotes 1 year ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community What do you think about my progress? I'm 3 months on minoxidil.

513 upvotes 1 month ago

The conversation is about a transgender individual's hair loss progress after 3 months on minoxidil, with speculation about additional treatments like HRT. Some users doubt minoxidil's effectiveness alone and suggest other factors are contributing to the hair growth.

community People that don’t have 4c hair which is mostly all races that aren’t black have it better than us. Yall can have a receding hairline like this and still pull it off but I end up looking like this with mine, even when I grow my hair out 😭

502 upvotes 7 months ago

Black individuals may embrace baldness better due to less contrast between hair and skin. Finasteride is suggested for hair loss management, and natural styles like buzz cuts are recommended.

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