research Extracellular vesicles derived from embryonic day 13 fetal mouse dermal fibroblasts exhibit potential antifibrotic activity
E13 fetal mouse fibroblast vesicles may help reduce scarring.
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5 / 1000+ results research 0034 Cross-species insights into hair follicle-T cell interactions in discoid lupus erythematosus: A comparison of human, canine and mouse models using spatial transcriptomics
Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.
research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration
This study found that topical application of TGF-β mimic promoted enhanced wound healing and tissue regeneration in mice, suggesting its potential as a therapeutic option for improving wound healing.
research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?
This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.
research MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model
In this study, a biofunctional hydrogel incorporating mesenchymal stem cell-derived small extracellular vesicles promoted wound healing and reduced scar tissue formation by modulating the immune response in a mouse skin injury model.
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5 / 54 resultscommunity Reducing Fibrosis in Hair Loss: Topical Pirfenidone
Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.
community Opinions on best microneedling protocol? Some thoughts...
Microneedling can enhance hair growth by improving minoxidil absorption and stimulating blood flow. Users discuss optimal needle depths, with some favoring shallow frequent needling for better absorption and others preferring deeper needling for stem cell activation.
community Has anybody ever found out, what these hardened, tight spots on the scalp (where most balding takes place) are and how they appear and how to make the disappear?
The conversation discusses hair loss and treatments like finasteride, minoxidil, and ketoconazole shampoo. Users suggest scalp massages, warm showers, and other methods to address scalp tension and tight spots, with some mentioning the potential effects of medications like escitalopram and probiotics.
community 50 year old male, been balding for 10+ years
A 50-year-old male has been using 0.5mg oral finasteride, 5% topical minoxidil, and weekly microneedling to combat hair loss, seeing progress with new hair growth. He plans to continue this regimen and evaluate results after 12 months.
community Microneedling at .25 everyday before applying Min
Daily microneedling at 0.25mm before applying minoxidil is debated, with some suggesting weekly microneedling is safer and more effective. Concerns include potential skin damage and systemic absorption, while alternatives like tretinoin are considered safer for enhancing minoxidil absorption.
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1 / 801 resultslearn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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