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research Significant Correction of Disease after Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia

109 citations , October 2007 in “American Journal of Human Genetics”

This study found that postnatal treatment with recombinant EDA normalized adult teeth, improved sweating, and restored normal lacrimation in dogs with XLHED, suggesting its potential as a treatment for the condition.

research Mutational spectrum of EDA, EDAR, EDARADD, and WNT10A genes in the largest cohort of Russian patients with hypohidrotic ectodermal dysplasia

February 2026 in “Orphanet Journal of Rare Diseases”

This study identified pathogenic or likely pathogenic gene variants in 70.1% of Russian families affected by hypohidrotic ectodermal dysplasia, expanding knowledge of causative mutations.

research Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies

9 citations , March 2015 in “International reviews of immunology”

This review discusses the relationship between ectodermal alterations and immunodeficiencies, particularly the roles of hyper-IgE syndrome, ectodermal dysplasia, and FOXN1 gene mutations, but it presents no new research findings.

research Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes

43 citations , February 2013 in “Developmental dynamics”

This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.

research Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

6 citations , August 2022 in “International Journal of Molecular Sciences”

This review summarizes the role of Ectodysplasin A signaling in skin appendage development and various diseases, noting potential clinical applications but reporting no new research findings.

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community Can someone please explain this transformation of Brighton FC coach?

177 upvotes 1 month ago

The Brighton FC coach's drastic hair change is speculated to be due to a hair system or transplant, with some suggesting he might have stopped using Minoxidil. Opinions vary on whether he had a transplant, wore a wig, or if the photos were mislabeled.

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