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Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

research Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations , June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

research Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

40 citations , July 2019 in “Journal of Investigative Dermatology”

In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

19 citations , November 2018 in “Nutrients”

This study reports that polyphenols from Annurca apples may safely promote hair growth and protect against chemotherapy-induced alopecia without interfering with chemotherapy regimens.

Cloning of Wrinkle-Free, a Previously Uncharacterized Mouse Mutation, Reveals Crucial Roles for Fatty Acid Transport Protein 4 in Skin and Hair Development

research Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development

93 citations , April 2003 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations , August 2014 in “Lipids”

This study found that unsaturated fatty acids are more abundant in the cortex of human hair than on its surface, and steryl glycoside-like lipids may help bind the cuticle to the cortex.

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community DHT Itch and Oily Scalp Explained (and how to fix it)

90 upvotes 3 months ago

Malassezia overgrowth can worsen oily scalp and inflammation, contributing to hair loss. Treatments include antifungal shampoos, C6/C8 MCT oil, low-dose isotretinoin, finasteride, and dutasteride.

community Check your vitamin d3 levels!!!

158 upvotes 2 months ago

Vitamin D3 deficiency and gut health, particularly H. pylori overgrowth, can impact hair growth and overall health. Treatments like Minoxidil and finasteride may be ineffective if these issues are not addressed.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Has anybody heard of this new cure?

2735 upvotes 8 months ago

A new hair loss treatment shows promise in mice but is unproven in humans. Effective treatments include finasteride and minoxidil.

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