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community Eirion ET-02( RS 5441) managed to defeat rodents, finally

in Technology 67 upvotes 1 year ago

ET-02 (RS 5441) shows promising results for hair growth, performing better in humans than in mice. There is debate over the effectiveness compared to minoxidil, with some users wanting more detailed data.

community Why does Pelage PP405 receive so much attention, while Eirion ET-02 seems to be almost forgotten?

30 upvotes 1 year ago

ET-02 is seen as promising for addressing hair loss and graying, but PP405 is more advanced in development and has better publicity. Some users plan to use both treatments alongside minoxidil and dutasteride.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community ICYMI: Eirion ET-02’s Successful Phase 1 Trial Results for Androgenic Alopecia Treatment

46 upvotes 1 year ago

ET-02 showed significant hair growth in five weeks, outperforming minoxidil, with a non-hormonal mechanism that avoids side effects of treatments like finasteride. A phase 2 trial is planned to further assess ET-02's efficacy and safety.

community I hope ET-02 or PP405 will be released in the next 4-5 years

18 upvotes 1 year ago

PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

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Research

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research Segmental hair analysis - a retrospective testosterone diary?

July 2022 in “Research Square (Research Square)”

This study found that hair testosterone concentrations show some consistency over time, but factors like hair washing and individual growth rates influence these levels, suggesting the need for careful sampling and analysis adjustments.

research The Spectrum of Skin Disease Among Indian Children

65 citations , January 2009 in “Pediatric Dermatology”

In this retrospective study at a New Delhi children's hospital, the authors found that pediatric skin diseases were most commonly infections and infestations, with bacterial infections and scabies leading, followed by eczemas.

research A global analysis of CNVs in Chinese indigenous fine-wool sheep populations using whole-genome resequencing

November 2019

This study constructed a genomic map of copy number variations in fine-wool sheep, revealing their potential impact on traits like growth, nutrient metabolism, and susceptibility to selection pressures.

research Hemorrhagic Cystitis in Allogeneic Stem Cell Transplantation: A Role for Age and Prostatic Hyperplasia

2 citations , October 2021 in “Research Square (Research Square)”

This study found that in patients undergoing allogeneic hematopoietic stem-cell transplantation, older age significantly increases the risk of hemorrhagic cystitis, especially in males, who are also affected by prostatic hyperplasia.

research The evaluation and management of hirsutism*1

195 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.

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