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Sequential Estrogen-Progestin Addition to Gonadotropin-Releasing Hormone Agonist Suppression for the Chronic Treatment of Ovarian Hyperandrogenism: A Pilot Study

research Sequential estrogen-progestin addition to gonadotropin-releasing hormone agonist suppression for the chronic treatment of ovarian hyperandrogenism: a pilot study.

2 citations , December 1994 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.

research Dermatological alterations induced by gynecological hormonal imbalances: Acne, hirsutism and alopecia

October 2025 in “World Journal of Biology Pharmacy and Health Sciences”

This review highlights the role of sex hormones in skin health, observing that hormonal changes throughout a woman's life can affect skin conditions such as acne and hair loss, with treatments involving hormonal therapies and the importance of a multidisciplinary approach.

research Differences in male and female pattern hair loss based on androgens, estrogen, iron, vitamin D, lipid metabolism, and genetic regulation

July 2026 in “Journal of Cutaneous and Aesthetic Surgery”

This review suggests that female and male hair loss patterns differ due to hormonal influences, metabolic factors, and genetic loci, with female pattern hair loss potentially occurring without androgen influence, highlighting the need for distinct clinical management approaches.

research Iatrogenic androgen and estrogen excess in a postmenopausal woman presenting with facial erythema, acne, and hirsutism

August 2009 in “International Journal of Dermatology”

This case report describes a postmenopausal woman who experienced facial erythema, acne, and hirsutism due to excess androgen and estrogen levels.

research Long-Term Effects of Sirolimus on Human Skin TSC2-Null Fibroblast‒Like Cells

1 citations , March 2021 in “Journal of Investigative Dermatology”

Sirolimus can reduce tumor cell size in TSC-related skin tumors, but continuous treatment is needed to maintain benefits.

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Community Join

5 / 793 results

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Is DUT better or worse than FIN?

in Finasteride/Dutasteride 62 upvotes 2 years ago

The conversation discusses the effectiveness of Dutasteride (DUT) and Finasteride (FIN) for hair loss. Users share varied experiences, with some finding DUT more effective and others experiencing side effects or no change, highlighting that individual responses can vary.

community I cannot even tolerate Nutrafol

in Product 6 upvotes 10 months ago

The user experienced side effects from finasteride and Nutrafol, opting for non-hormonal treatments like minoxidil, exercise, and a healthy lifestyle. Others discussed using Dutasteride, Biotin, and minoxidil with varying success and side effects.

community People who continue to lose hair on fin/dut, Are you on Nicotine?

in Research/Science 81 upvotes 1 year ago

Nicotine use, especially from vaping, may worsen hair shedding and reduce the effectiveness of finasteride and dutasteride. Quitting nicotine seems to improve hair health.

community 2+ Years of Finasteride treatment - Stopped hair-loss, got regrowth, but

24 upvotes 1 year ago

The user experienced successful hair regrowth with Finasteride and Minoxidil but developed erectile dysfunction and abdominal pain, possibly due to medication or lifestyle changes. They plan to consult a urologist and consider adjusting medication or trying supplements like zinc, DIM, or boron.

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Learn

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learn Alfatradiol

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.

learn Estradiol

Can Estradiol cause side effects in people without a hormonal imbalance? Estradiol can cause side effects even in hormonally balanced individuals.

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