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GlossaryERK Pathway (ERK signaling)

chain of proteins transmitting signals from cell surface to DNA

The ERK Pathway, also known as the Extracellular Signal-Regulated Kinase Pathway, is a chain of proteins in the cell that communicates signals from a receptor on the cell's surface to the DNA in the nucleus. This pathway plays a crucial role in regulating various cellular activities, including growth, division, and differentiation. It is particularly important in the context of hair biology, as disruptions in this pathway can influence hair growth and contribute to conditions like alopecia.

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research Platelet-Rich Plasma: Alopecia Areata and Autoimmune Destruction of the Hair

May 2018 in “Journal of dermatology and dermatitis”

PRP is a promising treatment for autoimmune hair loss but its exact workings are not fully understood.

research Careless Talk Costs Lives: Fibroblast Growth Factor Receptor Signalling and the Consequences of Pathway Malfunction

119 citations, November 2014 in “Trends in Cell Biology”

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

1 citations, April 2023 in “Science Advances”

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

research Epidermal Growth Factor Receptor as a Key Regulator of Immune Privilege

November 2022 in “Journal of Investigative Dermatology”

EGFR is crucial for preventing hair follicle inflammation and hair loss.

research Targeted Therapy in Melanoma

21 citations, February 2013 in “Clinics in Dermatology”

New treatments for advanced skin cancer are improving patient outcomes, but drug resistance and finding the right treatment combinations are still big challenges.

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community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Wait, so retinol actually helps with hair growth? I heard it was the other way around a while ago and just accepted it..

in Treatment 6 upvotes 5 years ago

Retinol can help with hair growth, contrary to previous beliefs. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles

17 upvotes 6 years ago

The conversation is about hair loss treatments, specifically discussing the effectiveness of Red Ginseng Extract in promoting hair growth. Other treatments mentioned include Minoxidil, finasteride, and RU58841.