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research MLPH-mediated activation of dermal papilla IGF-1 signaling drives human hair shaft elongation and anagen induction

February 2026 in “Biomedicine & Pharmacotherapy”

In this study, researchers developed EPO-derived peptides that enhanced hair growth by stimulating dermal papilla cells and increasing IGF-1 expression without triggering systemic erythropoietic effects in tested models, indicating a promising approach for treating hair loss.

research Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin

71 citations , May 2007 in “The FASEB journal”

This study found that human hair follicles express erythropoietin and its receptor, suggesting these follicles may use erythropoietin signaling to modulate apoptosis under stress conditions like hypoxia and chemotherapy.

research Transcriptome Sequencing Reveals Differences between Primary and Secondary Hair Follicle-derived Dermal Papilla Cells of the Cashmere Goat (Capra hircus)

81 citations , September 2013 in “PLoS ONE”

This study identified gene expression differences between dermal papilla cells from primary and secondary hair follicles in Cashmere goats, highlighting their roles in hair follicle morphogenesis.

research Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO

15 citations , March 2012 in “International journal of nanomedicine”

In this study, local injection of nanosized recombinant human erythropoietin at the injury site improved skin regeneration and re-epithelialization in a mouse model of deep second-degree burns through coexpression of specific receptors.

research Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice

17 citations , May 2010 in “Journal of Dermatological Science”

This study found that erythropoietin promotes hair growth by stimulating dermal papilla cells with functional erythropoietin receptors, enhancing hair shaft elongation and anagen phase in cultured human hair follicles and in mice.

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community Supplements regime/suggestions

4 upvotes 8 years ago

The conversation discusses hair loss treatments, including finasteride, pumpkin seed oil, castor oil, fish oil, and various supplements like NAC, glycine, and vitamin C. Opinions vary on the effectiveness of these treatments, with some users skeptical about their impact on hair loss.

community Brotzu lotion update

87 upvotes 8 years ago

A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.

community How do athletes maintain their hair transplants? Or do they not?

in Transplants 57 upvotes 1 year ago

Athletes often use finasteride to maintain hair transplants, but some avoid it due to potential hormonal effects. Notable examples include Mo Salah and Conor McGregor, while LeBron James has had multiple procedures with varying success.

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