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Androgens Trigger Different Growth Responses in Genetically Identical Human Hair Follicles in Organ Culture Reflecting Their Epigenetic Diversity in Life

research Androgens Trigger Different Growth Responses in Genetically Identical Human Hair Follicles in Organ Culture Reflecting Their Epigenetic Diversity in Life

19 citations , October 2017 in “The FASEB Journal”

Male hormones cause different growth in identical human hair follicles due to their unique epigenetic characteristics.

Vellus-To-Terminal Hair Follicle Reconversion Occurs In Male Pattern Balding And Is Promoted By Minoxidil And Platelet-Rich Plasma: In Vivo Evidence From A New Humanized Mouse Model Of Androgenetic Alopecia

research Vellus-To-Terminal Hair Follicle Reconversion Occurs In Male Pattern Balding And Is Promoted By Minoxidil And Platelet-Rich Plasma: In Vivo Evidence From A New Humanized Mouse Model Of Androgenetic Alopecia

October 2023 in “Acta dermato-venereologica”

Minoxidil and platelet-rich plasma can help turn thin hair into thicker hair in male pattern baldness.

research Women’s Hair Loss: Pathophysiological, Diagnostic and Therapeutic Aspects

October 2022 in “Reproductive health of woman”

Accurate diagnosis and personalized treatment are crucial for managing women's hair loss.

research Retinoic Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells

June 2025 in “Biomolecules”

RORA affects hair follicle stem cells' structure and movement, potentially helping treat hair loss.

research The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia

2 citations , January 2023 in “International Journal of Biological Sciences”

A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.

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Community Join

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community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

in Chat 138 upvotes 5 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community It's not just about your hair, it's also about YOU!

in Chat 73 upvotes 2 years ago

The user has been on Finasteride and oral Minoxidil for hair loss and experienced minimal side effects. They suggest that a healthy lifestyle, including good sleep, exercise, diet, skincare, and mental health care, may help reduce the perceived side effects of Finasteride, although another user disagrees, emphasizing that side effects can vary and may not be mitigated by lifestyle alone.

community Little Update - Min 6 Months and Fin 5 Months

in Progress Pictures 263 upvotes 1 year ago

The user shared a 6-month progress update on hair regrowth using Minoxidil and 5 months of Finasteride, along with a hair transplant of 4,200 grafts. Commenters reacted positively, discussing the effectiveness of these treatments and the impact on self-image.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 1 year ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 71 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

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