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Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease

research Integrated single-cell chromatin and transcriptomic analyses of human scalp reveal etiological insights into genetic risk for hair and skin disease

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study identifies gene-regulatory networks related to genetic variants in skin and hair diseases, suggesting that dermal papilla cells are crucial in androgenetic alopecia.

research Morphological Approach to Hair Disorders

38 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews various topics discussed at a workshop on hair disorders, focusing on hair biology, diagnosis, and challenges in therapy evaluation, without presenting new clinical findings.

research 464 Spatial transcriptomics links gene expression profiles to functional and structural traits of darkly pigmented skin

November 2025 in “Journal of Investigative Dermatology”

Dark skin has stronger barriers and structure due to specific gene activity.

research Mediator 1 ablation induces enamel-to-hair lineage conversion through enhancer dynamics

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.

research Defining a Region of the Human Keratin 6a Gene That Confers Inducible Expression in Stratified Epithelia of Transgenic Mice

44 citations , May 1997 in “Journal of Biological Chemistry”

This study found that regulatory sequences crucial for inducing K6a expression in response to epidermal injury are located in specific upstream regions of the K6a gene in transgenic mice.

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Community Join

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community Why Fin/Dut Isn't Working for You GPR133: a new hairloss mechanism + Steroid Hair Loss Deep Dive

6 upvotes 1 month ago

Hair loss may be linked to the GPR133 receptor, independent of the androgen receptor pathway. Treatments like finasteride, dutasteride, minoxidil, RU58841, and KX-826 show varying results, with hair loss persisting due to high testosterone and GPR133's role.

community I have a theory about hair loss

in Treatment 7 months ago

Hair loss is often linked to inflammation and DHT, with treatments like finasteride, dutasteride, and minoxidil being effective for many. Natural remedies like turmeric and oils are discussed, but medications are generally seen as more reliable for managing genetic hair loss.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

308 upvotes 1 year ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

137 upvotes 11 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

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Learn

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learn Beta Polypeptide

learn Epidermal Growth Factor

learn Thymosin Beta 4

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Clinics

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Hair Loss Treatments
Gene Lee Skin ClinicSan Diego, CA · US

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