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Attenuation of 5α-Reductase-Mediated Progesterone Metabolism Promotes Differentiation of Human Endometrial Stromal Cells for the Establishment of Pregnancy

research Attenuation of 5α-Reductase-Mediated Progesterone Metabolism Promotes Differentiation of Human Endometrial Stromal Cells for the Establishment of Pregnancy

January 2020 in “Nihon Yakuri Gakkai nenkai yoshishu”

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

research A Missing Piece: The Spiny Mouse And The Puzzle Of Menstruating Species

24 citations, May 2018 in “Journal of Molecular Endocrinology”

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization

4 citations, November 2022 in “Frontiers in endocrinology”

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

September 2024 in “International Journal of Molecular Sciences”

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

View more "endometrial stroma" in research →

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community Taking Charge of Your Hair: The "Big 3 Stack" Explained for 2023

in Research/Science 129 upvotes 1 year ago

The "Big 3 Stack" for hair loss treatment, which includes Minoxidil for hair density improvement, Ketoconazole shampoo for enhancing hair volume and thickness, and Finasteride for blocking hair loss causing hormones. Microneedling can boost Minoxidil's effects.

community The story of RU58841/ PSK3841

in Research 622 upvotes 3 months ago

RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.