69 citations
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April 2005 in “Forensic Science International”
This study suggests that degraded human hair shafts are highly resistant to contamination by exogenousDNA, making them a valuable source for forensic and ancient DNA analysis.
April 2023 in “Journal of Investigative Dermatology”
This study found that patients with Stevens-Johnson syndrome and toxic epidermal necrolysis exhibit lower levels and activity of DNase1, impairing NET degradation, and suggests DNase1 administration as a potential treatment.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”
In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.
January 2010 in “Acta Laboratorium Animalis Scientia Sinica”
This research reports that the ultra-high sulfur keratin promoter acts as a tissue-specific promoter in mouse hair follicles, as shown by induced expression of GFP and β-gal in that region post-transfection.
10 citations
,
July 1980 in “British Journal of Dermatology”
This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.
The user is using a combination of 6% minoxidil, 0.3% finasteride spray in the morning, and 5% RU58841 in the evening for hair loss, considering it an aggressive approach. They are concerned about absorption issues and prefer topical treatments to avoid systemic side effects, especially while using anabolic steroids.
The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.
Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.
Finasteride is used for hair loss, with mixed reports of no side effects and claims of long-term negative effects known as Post Finasteride Syndrome (PFS). The conversation debates the existence and causes of PFS, with differing opinions on whether it is psychological or real.
Dutasteride caused persistent hair shedding and no improvement for 18 months, leading to a switch back to finasteride. The user also uses oral minoxidil and plans to focus on better scalp health.