8 citations
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January 1987 in “Gynecological Endocrinology” This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.
1 citations
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January 2022 This study reported that a combination of Myo-inositol and D-chiro-Inositol improved clinical and laboratory parameters in teenage girls with PCOS compared to a placebo.
60 citations
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February 2010 in “Gynecological Endocrinology” This study suggests that adding metformin to diet and exercise improves insulin resistance and hyperandrogenism in women with PCOS, though lifestyle changes alone may enhance menstrual cycles.
December 2023 in “Advances in basic medical sciences.” In this cohort study, short-term treatment with metformin in overweight/obese women with PCOS significantly improved menstrual irregularities and lipid profiles (HDL and LDL levels), but did not significantly affect BMI, insulin, testosterone, or adipokine levels compared to the unexposed group.
2 citations
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January 2013 This study found that three months of metformin therapy improved acne, hirsutism, and menstrual irregularities in women with PCOS, along with hormonal and ultrasonographic changes.