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Glossary Elastin

protein enabling tissues to return to shape after stretching

Elastin is a protein found in connective tissues that allows them to resume their shape after stretching or contracting. It is crucial for the elasticity and resilience of tissues like skin, blood vessels, and lungs. In the context of hair, elastin contributes to the flexibility and strength of the hair shaft, helping it withstand various physical stresses.

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Research

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research Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions

14 citations , October 2021 in “Dermatology and Therapy”

This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.

research Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study

15 citations , December 2013 in “Clinical Cosmetic and Investigational Dermatology”

This study found that levels of the protein MAGP-1, important for skin elasticity, decrease with aging and photoexposure, potentially contributing to skin fragility, sagging, and enlarged pores.

research Mitigating GLP-1–Related Dermatologic Adverse Effects through Methylene Blue’s Antioxidant Action

June 2026 in “Annals of Clinical Pathology”

This review discusses how glucagon-like peptide-1 receptor agonists, used for type 2 diabetes and obesity, may cause skin aging and hair loss, and explores methylene blue as a potential protective treatment.

research 1447 Anti-senescence effect of extracellular vesicle from hyaluronic acid primed induced mesenchymal stem cells on aged human dermal fibroblast

April 2023 in “Journal of Investigative Dermatology”

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

research MP45-10 HISTOMORPHOMETRICAL EVALUATION OF THE CORPUS CAVERNOSUM OF HYPERTENSIVE RATS TREATED WITH 5-?-REDUCTASE INHIBITORS

April 2017 in “The Journal of urology/The journal of urology”

This study found that Sonic Hedgehog protein treatment enhanced the sprouting and regeneration of pelvic ganglia and cavernous nerves after injury, with localization of delivery affecting outcomes.

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Community Join

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community I’m 18 im doing prevention research but it may have gone a little bit further

in Research/Science 1 year ago

Hair loss is influenced by scalp tension, stress, and environmental factors, not just hormones. Treatments like tretinoin, microneedling, scalp massage, and Botox can reduce tension and improve hair health.

community My 11 month finasterid update as someone with diffused thinning characteristics

in Progress Pictures 218 upvotes 1 year ago

Finasteride improved hair thickness for someone with diffused thinning after 11 months, with no side effects. Patience and consulting a dermatologist are advised, and minoxidil is suggested for additional support.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 9 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )

1951 upvotes 5 months ago

Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.

community Anybody else notice improved skin/collagen on Dutasteride

6 upvotes 3 years ago

User switched from finasteride to combination dutasteride and finasteride for hair density improvement. They noticed less hair shedding and more youthful skin, with a reply suggesting less DHT could increase elastin in skin.

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Learn

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learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

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