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research Hair follicle stem cells repair wounds by converting effector T cells into regulatory T cells to shield against inflammation 2517

November 2025 in “The Journal of Immunology”

This study found that CD80 expression in wound-activated hair follicle stem cells induces Foxp3 expression in effector T cells, facilitating wound repair by converting them into regulatory T cells.

research 0054 Treg-targeted therapies restrain disease in a murine model of alopecia areata

July 2025 in “Journal of Investigative Dermatology”

Enhancing Tregs can protect against alopecia areata.

research The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema

84 citations , October 2007 in “The Journal of Immunology”

This study found that chronic eczema supports the expansion of myeloid suppressor cells, which contribute to silencing autoreactive T cells and partially promote hair regrowth in alopecia areata.

research Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations

22 citations , September 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review highlights the possible role of T regulatory cells in the immune-related mechanisms of alopecia areata but reports no new clinical findings.

research Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature

25 citations , November 2020 in “Cell Reports Medicine”

Developing human skin has immune cells with memory-like features.

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community Do you believe these studies are real or just fear mongering

in Finasteride/Dutasteride 157 upvotes 11 months ago

Finasteride can regrow hair but may cause depression and suicidal thoughts in some users. The connection between finasteride and mental health issues is debated, with some attributing it to pre-existing conditions or stress.

community Publication concludes finasteride is a associated with a 60% risk of persistent sexual dysfunction.

345 upvotes 6 months ago

Finasteride is not linked to a 60% risk of persistent sexual dysfunction; this figure applies only to those already experiencing sexual issues. Most users do not have side effects, and the study's methodology is criticized for selection bias.

community DHT is about to get smashed ….

802 upvotes 2 years ago

The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

community I cannot sleep anymore, what should I do

7 upvotes 1 year ago

Finasteride may cause sleep disturbances, with some users experiencing insomnia. Reducing the dosage, switching brands, or trying Dutasteride might help.

community Minoxidil and facial aging

50 upvotes 6 years ago

Minoxidil may cause facial aging or wrinkles, though opinions vary. Some users report side effects like dark circles and facial bloating, while others attribute changes to genetics or other factors.

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