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research The Anti-Muscle Atrophy Effects of Ishige Sinicola in LPS-Induced C2C12 Myotubes Through Antioxidant and Anti-Inflammatory Actions

1 citations , September 2023 in “Applied sciences (Basel)”

Ishige sinicola extract may help prevent muscle atrophy through its antioxidant and anti-inflammatory effects.

research The Role of R-Spondins and Their Receptors in Bone Metabolism

25 citations , May 2016 in “Progress in Biophysics & Molecular Biology”

R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.

research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development

147 citations , September 2006 in “Developmental Cell”

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

research Comparative Ubiquitinomics of Human Skin Reveals Insulin Receptor Ubiquitination as a Regulator of Collagen Secretion

December 2025

Ubiquitination of the insulin receptor regulates collagen secretion in human skin.

research Current Status of Fractional Laser Resurfacing

44 citations , July 2015 in “JAMA Facial Plastic Surgery”

Fractional laser resurfacing is effective and safe for skin treatment, with benefits like less downtime and a low risk of adverse events.

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Community Join

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community hair loss treatment alternatives and ideas to improve gain

in Treatment 3 upvotes 3 years ago

The post discusses using finasteride, minoxidil, ketoconazole, and a dermaroller for hair loss, along with spearmint capsules, pueraria mirifica, saw palmetto, biotin, and vitamins. The user is also considering microdosing finasteride with trans treatment and mentions the potential of herbal enemas and hair systems.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 1 year ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 126 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community 26M is this progress or loss

dutuser in Journals / Progress Pictures 57 upvotes 6 months ago

The user shared progress pictures comparing hair from February 2024 to September 2025, using Dutasteride since May 2020 and Minoxidil since April 2023. Another user noted that progress can't be assessed without before and after photos spaced months apart.

community 24M, 1 Year on Fin+Min with Stabilized Loss, Seeking Advice on Next Steps

Mdahl in General 98 upvotes 2 months ago

The user has been using Minoxidil and Finasteride for a year with no change in hair density, though hair loss has stabilized. They are considering increasing the dose or exploring other options like Dutasteride or a hair transplant.

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