research Related Topic: Drug Permeation Through Hair Follicles
This chapter reviews the hair follicle's role in drug and chemical penetration through the skin but does not present new experimental findings.
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research Penetration and distribution of three lipophilic probes in vitro in human skin focusing on the hair follicle
This study found that increasing a drug's lipophilicity and adding ethanol to the donor phase can enhance its delivery to the hair follicle, although the precise transport mechanism remains unclear.
research Photo-responsive fibers as artificial hairs in an in-vitro model for transdermal drug delivery
This study reports the development of an artificial skin membrane incorporating hair follicles, intended as an in vitro model to better estimate drug permeation with less variability than current models used in transdermal drug delivery research.
research A discourse on human hair fibers and reflections on the conservation of drug molecules
This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.
research Diffusion properties of model compounds in artificial sebum
This study found that drug transport through artificial sebum varies depending on the compound, suggesting that sebum-targeted delivery can be optimized by selecting compounds based on their distinct transport profiles in sebum versus skin.
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5 / 1000+ resultscommunity New warning by FDA on topical finasteride
The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.
community PP405 (JXL069) Is Confirmed: Here’s Everything I’ve Learned After a Year of Testing
JXL069, also known as PP405, did not lead to hair regrowth after a year of testing. The lack of results may be due to formulation issues, leading to a final attempt with an improved vehicle.
community Jxl069 (pp405 api) week 8 update
The user shared minimal results from using JXL-069 for hair loss, noting a slight lengthening of vellus hairs and plans to switch to a prodrug variant due to limited effectiveness. They also mentioned using finasteride and minoxidil, which have plateaued in results.
community risks with finasteride and dutasteride
Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.
community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that
Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.
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2 / 801 results- Baricitinib: How did a drug for arthritis end up helping people regrow hair from alopecia areata? Baricitinib helps regrow hair by targeting the autoimmune response in alopecia areata.
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