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research Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation

12 citations , January 2022 in “Cells”

This study found that early passage dermal papilla cell-derived extracellular vesicles, combined with specialized medium, helped adipose-derived stem cells develop dermal papilla-like properties.

research Bioactives in Chinese Proprietary Medicine Modulates 5α-Reductase Activity and Gene Expression Associated with Androgenetic Alopecia

6 citations , April 2017 in “Frontiers in Pharmacology”

This study found that several compounds from Yangxue Shengfa capsule may promote hair growth by enhancing cell proliferation in vitro, suggesting potential use in treating androgenetic alopecia.

research Analysis of differentially expressed genes of dermal papillae cells with aggregative behavior in uitro

January 2009 in “China Practical Medicine”

This study found that several genes, including capping protein, palladin, VEGF, and HSPC-related clones, might cooperatively influence the aggregation, proliferation, and cycle control of dermal papilla cells, potentially affecting hair follicle behavior.

research Establishment of SV40T-transformed human dermal papilla cells and identification of dihydrotestosterone-regulated genes by cDNA microarray

13 citations , June 2007 in “Journal of Dermatological Science”

This study identified several genes regulated by dihydrotestosterone in an SV40T-transformed human dermal papilla cell line, which may play a role in androgen-mediated hair growth regulation.

research 3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration

15 citations , March 2022 in “Acta Biomaterialia”

This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.

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community 41/M Seeking Advice on Alternatives to Fin/Dut Due to Gyno

in General 134 upvotes 9 months ago

A 41-year-old South Asian individual feels hopeless about hair loss and cannot use oral finasteride or dutasteride due to existing gynecomastia. They are seeking advice on alternative treatments.

community What should I do 18M facing extreme hair thining and dandruff

in General 161 upvotes 8 months ago

An 18-year-old is experiencing severe hair loss and dandruff, feeling stressed and unable to commit to Minoxidil or handle finasteride side effects. They have tried natural oils, anti-hair fall shampoo, and consulted a dermatologist without success, and are seeking affordable treatment options.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

18 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 3 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

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Nicolas DPC
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