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Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations, December 2011 in “Journal of Investigative Dermatology”

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

research Costunolide Promotes the Proliferation of Human Hair Follicle Dermal Papilla Cells and Induces Hair Growth in C57BL/6 Mice

21 citations, May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

research Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

8 citations, January 2016 in “Cells tissues organs”

Norepinephrine helps skin cells grow, which is important for hair growth.

Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers

research Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers

40 citations, June 2013 in “Biomaterials”

Scientists created 3D hair-like structures that could help study hair growth and test treatments.

research LncRNA-XIST Promotes Dermal Papilla Induced Hair Follicle Regeneration by Targeting miR-424 to Activate Hedgehog Signaling

11 citations, March 2020 in “Cellular Signalling”

XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Unofficial Dermapen/Roller Guide

in Treatment 253 upvotes 5 years ago

Treatments for hair loss, including microneedling (dermarolling and dermapen) and the use of minoxidil, finasteride, and RU58841. It provides detailed information about cost and usage of the various treatments, as well as potential side effects.

community Information regarding Follicusan DP?

in Product 3 upvotes 1 year ago

Follicusan DP is discussed as a potential alternative to Minoxidil without side effects, but information is scarce. It is noted to be of German origin and details on its mechanism are limited.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.

6 upvotes 4 years ago

The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.

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