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Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations, December 2011 in “Journal of Investigative Dermatology”

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

research Dermal Papilla Cells and Melanocytes Response to Physiological Oxygen Levels Depends on Their Interactions

7 citations, June 2021 in “Cell Proliferation”

Low oxygen levels improve the function of hair and skin cells when they are in direct contact.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations, June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

research Keratinocytes Maintain Compartmentalization Between Dermal Papilla and Fibroblasts in 3D Heterotypic Tri-Cultures

16 citations, August 2019 in “Cell Proliferation”

Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.

research Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

51 citations, April 2020 in “Cells”

Special cell particles from macrophages can help hair grow.

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Community Join

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community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Oxytocin, empathy, hair, and cinnamon

in General 138 upvotes 6 months ago

Low oxytocin levels in hair are linked to reduced empathy and may affect hair growth. Cinnamic acid can promote hair growth by activating oxytocin receptors.

community personal progress (~8-9months) with fin(1.25mg)/min/needling/niz

in Progress Pictures 571 upvotes 2 years ago

A user's personal hair loss progress with treatments, including finasteride (1.25mg), minoxidil, needling, and Nizoral; and advice from other users on how to perform the needling correctly.

community Checking in with my post-fin symptoms

in Finasteride 6 upvotes 8 years ago

A user reports persistent sexual side effects three months after stopping finasteride, despite a healthy lifestyle and supplements. They express concern over the lack of libido and infrequent erections.

community 5 months (.015% fin topical, 5% min, Microneedle .75mm) - How's the Progress?

in Is this regrowth? 30 upvotes 5 months ago

User is using a homemade topical treatment with .015% finasteride, 5% minoxidil, and microneedling at .75mm depth. They also use 2% ketoconazole shampoo, various oils, and are considering increasing finasteride concentration due to mixed results.

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