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GlossaryAutosomal Dominant Inheritance

one mutated gene from either parent can cause a trait

Autosomal Dominant Inheritance is a pattern of genetic transmission where only one copy of a mutated gene from either parent is sufficient to cause a particular trait or disorder. This means that if one parent carries the dominant gene, there is a 50% chance that their child will inherit the condition. This type of inheritance can be seen in conditions like certain forms of alopecia, where the presence of a single altered gene can lead to hair loss.

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research Uncombable Hair (Pili Trianguli Et Canaliculi): Evidence for Dominant Inheritance with Complete Penetrance Based on Scanning Electron Microscopy

33 citations , September 1987 in “American Journal of Medical Genetics”

Uncombable hair is inherited dominantly with complete penetrance.

research Familial Hypotrichosis of the Scalp: Autosomal Dominant Inheritance in Four Generations

17 citations , January 1991 in “Acta Dermato Venereologica”

A family had a genetic condition causing hair loss on the scalp, passed down through four generations.

research Autosomal Dominant Inheritance of Alopecia Congenita with Keratosis Palmo-Plantar

April 1977 in “Pediatric Research”

research Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V

6 citations , July 2021 in “Frontiers in Genetics”

A gene variant causes a skin and hair disorder by disrupting protein balance.

research Semidominant Inheritance in Epidermolytic Ichthyosis

10 citations , April 2013 in “Journal of Investigative Dermatology”

Epidermolytic ichthyosis can be inherited in a semidominant way with mild symptoms in carriers.

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community Why balding gets worse in every generation?

in Chat 81 upvotes 1 year ago

Balding seems to worsen with each generation, possibly due to stress, diet, and environmental factors. The user started treatments like Minoxidil and finasteride.

community Why some people experience problems on Finasteride/Dutasteride (my theory)

in Research/Science 18 upvotes 2 weeks ago

Some people have side effects from finasteride and dutasteride due to hormonal predisposition, especially if DHT dominant. Alternatives like RU58841, Pyrilutamide, and Breezula are suggested to target scalp androgen receptors without altering overall hormones.

community What to look Forward to in 2025

in Research/Science 20 upvotes 11 months ago

Hair loss treatments are advancing, with Coegin Pharma's FOL005 expected this year and Breezula potentially later. Pyrilutamide is available but not very effective, while Kintor's products face skepticism; traditional treatments like finasteride and minoxidil remain dominant.

community 3 yrs after transplant and massive thinning

in Transplants 23 upvotes 4 years ago

User experienced hair loss after weight lifting, had a successful hair transplant, but later faced significant thinning. Current treatment includes finasteride, minoxidil, dermal rolling, and supplements.

community don't deny the truth you know in your heart of hearts

in Satire 1977 upvotes 10 months ago

Hair loss treatments like finasteride, minoxidil, and ketoconazole shampoo are discussed humorously, with skepticism about future cures. Users express frustration over the lack of a permanent solution and joke about investing in stocks or using time travel to solve baldness.

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