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Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

research Effect of DNA aptamer through blocking of negative regulation of Wnt/β‐catenin signaling in human hair follicle dermal papilla cells

May 2023 in “Skin research and technology”

This study found that WD-aptamer increased β-catenin expression and promoted human hair follicle dermal papilla cell proliferation by interfering with the CXXC5-Dvl1 interaction in the Wnt signaling pathway.

research Effects of Oxidative Stress Prevention Using DNA Aptamer (Aptamin C®) in Keratinocyte

1 citations , January 2021 in “Clinical Dermatology Open Access Journal”

This study observed that the Aptamin C® and vitamin C complex had effective ROS-scavenging and anti-inflammatory effects on human skin in both in vitro and clinical tests.

research 525 Aptamer-Based Targeted Therapy for wound healing and hair growth promotion

November 2024 in “Journal of Investigative Dermatology”

Aptamers can improve wound healing and promote hair growth.

research Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion

June 2025 in “Molecular Therapy — Nucleic Acids”

In this study, researchers identified a specific DNA aptamer, Ap.OR2AT4.17, that effectively prolonged hair growth and increased hair shaft elongation in organ-cultured human hair follicles by targeting the olfactory receptor OR2AT4. This finding suggests the aptamer's potential as a novel therapy for hair loss disorders.

research Smart DNA biosensor for in vitro detection of androgen receptor mRNA

January 2020

This study developed a novel Smart DNA Biosensor for easy and efficient primary diagnosis of androgen receptors overexpression, which may aid in the rapid differential diagnosis of conditions like acne and androgenetic alopecia.

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Community Join

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community DNA test result is incredible !

in Technology 31 upvotes 7 months ago

The conversation discusses a personalized hair loss treatment plan based on DNA test results, recommending Minoxidil, Dutasteride, 17-alpha Estradiol, Cetirizine, and PRP sessions. The test identifies a high risk of hair loss due to DHT but a good response to Minoxidil, suggesting a tailored approach to treatment.

community DNA Test for better suited treatment?

3 upvotes 11 months ago

The conversation is about hair loss treatments, specifically discussing the use of dutasteride, minoxidil, and the potential benefits of a DNA test and PRP therapy. Opinions vary, with some users skeptical about the DNA test and PRP, suggesting sticking with current treatments.

community DNA Trichotest reliable? & topical spironolactone for Cis males

1 upvotes 1 year ago

The DNA Trichotest is considered unreliable for predicting hair loss treatment responses, and topical spironolactone is questioned for its effectiveness and safety in cis males. Finasteride and Dutasteride are recommended as more reliable treatments for androgenic alopecia.

community DNA Testing by Roots by Genetic Arts

4 upvotes 2 years ago

A user shared their positive experience with Roots by GA, a company that creates personalized hair loss treatments based on DNA analysis, which confirmed their inability to tolerate finasteride. The user is satisfied with their progress 30 days after a hair transplant and the customized formula they received.

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