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5α-Reductase Inhibitor Therapy: Should Physicians Be Concerned With Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients?

research 5α-Reductase inhibitor therapy: Should physicians be concerned with persistent diminished libido, erectile dysfunction and depression in a subset of patients?

October 2010 in “Journal of Men's Health”

Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

research AB40. Sexual side effects of medical treatment of BPH

September 2014 in “PubMed Central”

This review discusses the sexual side effects of medical and surgical treatments for benign prostatic hyperplasia, such as erectile dysfunction and changes in ejaculation, but presents no new clinical findings.

research Oral Finasteride Presents With Sexual-Unrelated Withdrawal in Long-Term Treated Androgenic Alopecia in Men.

3 citations , October 2015 in “PubMed”

This study found that sexual side effects occurred in a small percentage of patients using combined finasteride and minoxidil, but these were not common reasons for discontinuing treatment.

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations , June 2018 in “Urology”

This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.

research Impact of Alpha Blockers, 5-alpha Reductase Inhibitors and Combination Therapy on Sexual Function

11 citations , August 2014 in “Current Urology Reports”

This review discusses the known effects of medications for benign prostatic hyperplasia on sexual function and mechanisms of dysfunction but reports no new clinical results.

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community How are your experiences with Dutasteride?

in Finasteride/Dutasteride 38 upvotes 1 year ago

Dutasteride is often preferred over Finasteride due to fewer side effects and better hair regrowth. Initial side effects like lowered libido may occur but typically diminish over time.

community How is dht not beneficial to you?

in Finasteride/Dutasteride 111 upvotes 7 months ago

DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

community Dutasteride and my semen production

in Finasteride/Dutasteride 74 upvotes 1 year ago

A user experienced sexual side effects, including reduced semen production and numbness, after switching from finasteride to dutasteride for hair loss. They decided to stop dutasteride to prioritize their sexual health and may return to finasteride if issues resolve.

community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community 60 days on topical minoxidil 5% + 0.1% finasteride.

in Progress Pictures 377 upvotes 1 year ago

The user is happy with hair regrowth after 60 days using topical minoxidil 5% and finasteride 0.1%, along with a dermaroller. They report no significant side effects and plan to continue treatment for a year.

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