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Both amodimethicone and dimethicone copolyol amine are effective hair conditioners.

This study found that only minoxidil encapsulated in cationic vesicles significantly promoted hair growth in mice, likely due to its higher retention on the skin.

This study found that dimethicone with high molecular weight improved hair surface characteristics, while dimethicone copolyol and amodimethicone enhanced manageability by reducing friction or aiding styling on damaged hair.