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Chronic Exposure With 5-Alpha Reductase Inhibitor Ameliorates Anxiety and Depression-Like Behaviors by Reducing Systemic Oxidative Stress in D-Galactose-Induced Aging Male Rats

research Chronic Exposure with 5‐Alpha Reductase Inhibitor Ameliorates Anxiety and Depression‐like Behaviors By Reducing Systemic Oxidative Stress in D‐galactose‐Induced Aging Male Rats

December 2023 in “Alzheimer's & dementia”

In this rodent study, researchers found that the drug finasteride may reduce anxiety and depression-like behaviors in a model of aging, despite inducing metabolic disturbances and depressive-like behaviors in young rats, suggesting potential considerations for its use in elderly populations.

The Interaction Between Finasteride and Corticosterone Levels: Implications for Depression and Anxiety-Like Behavior and Hippocampal Synaptic Plasticity in Male Rats

research The interaction between finasteride and corticosterone levels: implications for depression-, and anxiety-like behavior and hippocampal synaptic plasticity in male rats

May 2025 in “Psychopharmacology”

In this study, chronic finasteride administration in male rats led to depression- and anxiety-like behaviors only in specific tests and moderately affected hippocampal synaptic plasticity, possibly due to adaptive plasma corticosterone level changes over time.

research Repeated finasteride administration induces depression-like behavior in adult male rats

19 citations , March 2019 in “Behavioural Brain Research”

This study found that repeated finasteride administration in male Wistar rats led to increased depression-like behavior, suggesting an animal model for investigating finasteride's neuropsychiatric effects is viable.

research Acetate meliorates depressive-like behaviour in a rat model of PCOS through suppression of HDAC2 expression and DNA methylation

1 citations , May 2022 in “Research Square (Research Square)”

The study demonstrates that acetate treatment may alleviate PCOS-associated depression in rats by reducing neuroinflammation and modifying epigenetic changes in the brain.

research Administration of finasteride modulates depressive-like behavior in the forced swim task of male rats

January 2012

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community Common hair-loss drug consistently associated with higher rates of psychiatric harm

in Research/Science 183 upvotes 11 months ago

Finasteride and dutasteride can cause psychiatric side effects like depression and suicidal thoughts in some users, especially those with a history of mental health issues. While some users experience positive hair growth results, others face severe psychological effects, raising concerns about their safety and the need for careful monitoring.

community Discussion on Finasteride and life.

in Chat 166 upvotes 1 year ago

Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

community Topical Dutasteride (Switching from Oral) Proven results

23 upvotes 5 years ago

Switching from oral to topical dutasteride may reduce side effects like anxiety and depression while maintaining hair health. Combining it with minoxidil, Nizoral, and dermarolling could be effective for hair preservation.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone

in Research/Science 163 upvotes 1 year ago

Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.

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