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In this study, the researchers observed that both standard body and facial depilatory creams caused significant skin injury in mice, with varying effects depending on the mouse strain and exposure time, although both formulations were effective for hair removal.

This study found that ingesting seeds from the Lecythis ollaria tree may cause hair loss and other toxic effects in animals.

This study found that a papain-containing cream had a significantly greater depilatory effect and altered skin morphology more than a papain-containing gel when applied to mice.

This study found that electric shaving was the most effective and safest method for preoperative hair removal in mice, compared to depilatory cream and sodium sulfide, which negatively affected wound healing.

This study investigated the safety and effectiveness of two thioglycolate chemical depilatory creams for full genital hair removal in men and women, finding acceptable dermal tolerance despite some instances of irritation, supporting their use for pubic hair grooming.