7 citations,
April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology” 11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.
November 2024 in “Frontiers in Endocrinology” This study explored the presence of glucocorticoids and mineralocorticoids in hair follicles to identify potential biomarkers for adrenal-related endocrine disorders. Using a novel extraction protocol, hair samples from 15 healthy volunteers were analyzed, revealing that all targeted steroids were detectable above the lower limit of quantification. Notably, deoxycortisol, deoxycorticosterone, and aldosterone were detected for the first time in men, and 18-hydroxycorticosterone was detected in both genders. The study found that deoxycortisol and deoxycorticosterone showed significant fluctuation along the hair follicle, while other steroids remained consistent. The findings suggest that these steroids in hair follicles could serve as reliable biomarkers for diagnosing conditions like hypoaldosteronism, primary hyperaldosteronism, Cushing’s syndrome, and congenital adrenal hyperplasia.
150 citations,
November 2007 in “The Journal of Clinical Endocrinology and Metabolism” About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.
2 citations,
April 2013 in “Expert Review of Endocrinology & Metabolism” Identifying nonclassic congenital adrenal hyperplasia and carriers of CYP21 mutations is challenging, and genetic counseling is recommended due to their prevalence.
5 citations,
March 2013 in “BMJ case reports” Gastric bypass surgery improved a woman's hormonal disorder without the need for medication.