research Telogen effluvium. New concepts and review
This article proposes five mechanisms for telogen effluvium based on changes in the follicular cycle, which are supported by clinical findings, highlighting the condition's diverse causes.
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research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells
This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.
research Delayed hair cycle in mnd2 mutant mice lacking HtrA2 serine protease activity
This study found that HtrA2 inactivation in mnd2 mice is associated with delayed hair cycle phases and growth retardation of adipocytes, suggesting HtrA2's role in regulating adipogenesis-related hair growth.
research Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model
This study found that foot shock stress prolonged the telogen stage and delayed anagen induction in the hair cycle of non-depilated mice, potentially through stress-induced actions of substance P.
research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber
This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.
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5 / 1000+ resultscommunity EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.
Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.
community On Fin 5 days a week and dut twice a week and still rapidly losing hair. HOW?? 9 months on fin!
A user using finasteride and dutasteride to treat hair loss, but still losing hair rapidly after stopping minoxidil. Replies suggest that the user should try oral minoxidil or switch to dutasteride for better results.
community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect
PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.
community Nothing happened till I was exactly 11 months off fin+min
After stopping finasteride and minoxidil, the user experienced significant hair shedding 11 months later, despite not noticing any hair loss during that period. The user initially took these treatments to regrow temple hair but did not see significant results and is now concerned about the delayed shedding.
community Totally confused by doctors opinions, would appreciate some clarity
The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.
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2 / 801 results- Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.
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