This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.
This study found that prenatal exposure to finasteride in pregnant rats significantly disrupted male reproductive development, confirming its use as a positive control for androgen-related reproductive effects.
6 citations
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September 2021 in “Autophagy” In this study on mouse preputial glands, suppressing ATG7-dependent autophagy delayed age-related changes, affected lipid metabolism, and reduced pheromone production, highlighting autophagy's roles in glandular homeostasis and cell breakdown.
86 citations
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March 1993 in “Toxicology and Applied Pharmacology” Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.
January 2020 in “Research Portal Denmark” This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.