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A Neglected Case of Systemic Lupus Erythematosus Presenting with Degos' Skin Disease and Diffuse Non-Scarring Alopecia with Dramatic Response to Treatment, Clinically and Dermoscopically

research A Neglected Case of Systemic Lupus Erythematosus Presenting with Degos' Skin Disease and Diffuse Non-Scarring Alopecia with Dramatic Response to Treatment, Clinically and Dermoscopically

April 2024 in “African Journal of Biological Sciences”

The patient with lupus and Degos' disease showed significant improvement with treatment.

research Mutations in Gamma-Secretase Subunit-Encoding PSENEN Underlie Dowling-Degos Disease Associated with Acne Inversa

87 citations , March 2017 in “Journal of Clinical Investigation”

PSENEN gene mutations can cause both Dowling-Degos disease and acne inversa.

research Atrophying Squamous Papulous Dermatitis (Degos Disease): Nine Years of Follow-Up

February 2010 in “Journal of The American Academy of Dermatology”

A woman with Degos disease managed her condition for nine years with medications and had two healthy pregnancies, while a separate finding suggests a possible link between female pattern hair loss and high blood pressure.

research The Color of Skin: White Diseases of the Skin, Nails, and Mucosa

4 citations , July 2019 in “Clinics in Dermatology”

The document concludes that while white skin, nail, and mucosa diseases increase skin cancer risk, they are generally harmless, especially compared to darker pigmentation conditions.

research Pleiotropic Role of Notch Signaling in Human Skin Diseases

29 citations , June 2020 in “International Journal of Molecular Sciences”

Notch signaling disruptions can cause various skin diseases.

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community When could we expect pp405 to hit the market?

in Research/Science 32 upvotes 6 months ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Update : 7 months on DUT every other day

in Is this regrowth? 100 upvotes 3 months ago

The user experienced significant hair improvement after 7 months of using Dutasteride (DUT) every other day, with no side effects, unlike previous experiences with Finasteride (FIN) and Minoxidil (MIN). The user plans to continue DUT for up to 24 months and is considering a hair transplant for further results.

community (M23)Been on DUT for a year and 1 month- so is a transplant not a good option if DUT doesn’t work🤷‍♂️

in Progress Pictures 25 upvotes 11 months ago

The user has been using Dutasteride for over a year for hair loss and is considering a hair transplant if it doesn't work. Suggestions include adding Minoxidil and microneedling, but some advise against a transplant as the current treatment seems effective.