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Antiandrogen Treatment with Spironolactone and Linestrenol Decreases Bone Mineral Density in Eumenorrhoeic Women with Androgen Excess

research Antiandrogen Treatment with Spironolactone and Linestrenol Decreases Bone Mineral Density in Eumenorrhoeic Women with Androgen Excess

26 citations , January 1994 in “Hormone and Metabolic Research”

This study found that one year of antiandrogen treatment with spironolactone significantly decreased bone mineral density in young women with androgen excess.

research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation

July 2024 in “Journal of Investigative Dermatology”

Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.

The Effect of Finasteride on the Expression of Vascular Endothelial Growth Factor and Microvessel Density: A Possible Mechanism for Decreased Prostatic Bleeding in Treated Patients

research The Effect of Finasteride on the Expression of Vascular Endothelial Growth Factor and Microvessel Density: A Possible Mechanism for Decreased Prostatic Bleeding in Treated Patients

90 citations , January 2003 in “The Journal of Urology”

This study found that finasteride significantly reduced VEGF expression and microvessel density in prostatic suburethral tissue, suggesting a mechanism for decreased bleeding in patients with benign prostatic hyperplasia.

research Decreased lipin 1β expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome

20 citations , October 2008 in “European journal of endocrinology”

This study found that lipin 1β expression in both visceral and subcutaneous adipose tissue is significantly lower in PCOS patients compared to controls, suggesting its involvement in the pathogenesis of insulin resistance.

research IMPROVEMENT OF ALOPECIA AND DECREASES IN HAIR CORTISOL AND DIHYDROTESTOSTERONE CONCENTRATIONS AFTER THE TOPICAL USE OF PLANT EXTRACTS IN MEN WITH ANDROGENETIC ALOPECIA

August 2021 in “Asian Journal of Pharmaceutical and Clinical Research”

In this randomized trial, a solid shampoo formulated with plant extracts was more effective than placebo in improving androgenetic alopecia and reducing hair cortisol and DHT concentrations in men.

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community For how many years did finasteride allow you to maintain the same hair density?

in Finasteride/Dutasteride 5 upvotes 1 month ago

Finasteride has helped users maintain hair density for varying durations, with some experiencing effectiveness for up to 20 years, while others noticed a decline after 4 to 6 years and switched to dutasteride. Users also reported occasional shedding and some switched treatments when effectiveness decreased.

community Dutasteride + oral minoxidil: strong regrowth by Jan 2026, then mid-scalp density loss without current shedding

3 upvotes 4 months ago

The user experienced hair regrowth with dutasteride and oral minoxidil from October 2025 to January 2026, but mid-scalp density decreased afterward despite continued treatment. Ketoconazole improves scalp condition, but stopping it worsens hair appearance.

community Been on treatment for 2 years, hair density is just getting worse

6 upvotes 1 year ago

The user has been using finasteride, dutasteride, minoxidil, and RU58841 for hair loss but is experiencing worsening hair density despite treatment. They are frustrated and confused as their hairline remains unchanged, but the overall hair thickness has decreased significantly.

community Alfatradiol causing shedding ?

1 upvotes 1 year ago

The user experienced a sudden decrease in hair density after starting alfatradiol while already using finasteride. Another user mentioned that initial shedding can occur with hair loss treatments, but it may not last long.

community Topical Melatonin, Hair Loss/Growth, and Seb Derm (Seborrheic Dermatitis)

13 upvotes 3 years ago

Topical melatonin was found to significantly increase hair density and decrease scalp conditions like seborrheic dermatitis. The user is considering using it alongside finasteride and oral minoxidil for treating hair loss and scalp health.

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learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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