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GlossaryDNA damage response (DDR)

cellular mechanisms detect and repair damaged DNA to maintain integrity

The DNA damage response (DDR) is a complex network of cellular processes that detect and repair damage to the DNA, ensuring the integrity of the genetic material. When DNA is damaged by factors like UV radiation or chemicals, DDR mechanisms activate to either fix the damage or, if repair is not possible, trigger cell death to prevent the propagation of faulty DNA. This system is crucial for preventing mutations that could lead to diseases such as cancer.

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research Induction Of Tissue-Specific Premature Stem Cell Aging Promotes Senescence-Like Phenotypes In Remote Multiple Organs

November 2022 in “Journal of Investigative Dermatology”

Aging in one type of stem cell can cause aging-like changes in various organs.

research DNA Damage Response Mediates Pressure Overload-Induced Cardiomyocyte Hypertrophy

42 citations , February 2019 in “Circulation”

Targeting ATM could help manage heart cell enlargement due to pressure overload.

research Development of Fluridil, a Topical Suppressor of the Androgen Receptor in Androgenetic Alopecia

5 citations , July 2003 in “Drug Development Research”

Fluridil promotes hair growth safely and effectively for androgenetic alopecia.

research The Effect of 1,25-Dihydroxyvitamin D3 on Cultured Human Hair Follicle Cells from a Patient with Vitamin D-Dependent Rickets Type II with Alopecia

2 citations , February 1990 in “PubMed”

DDR-II hair follicle cells don't respond to 1, 25-dihydroxyvitamin D3, aiding diagnosis.

research Review of the Effects of 17α-Estradiol in Humans: A Less Feminizing Estrogen with Neuroprotective Potential

26 citations , February 2009 in “Drug Development Research”

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

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community Soo... i was pretty bored and was just brainstorming and ended up thinking about gt20029

in Chat 6 upvotes 3 years ago

The conversation discusses maintaining hair regrowth using minoxidil and finasteride and whether using gt20029, which degrades androgen receptors, would affect this. Fluridil, a similar treatment, can disable over 90% of active androgen receptors.

community Goodbye tressless. I’ve decided to give in to my hairloss.

in Update 597 upvotes 3 years ago

Kitchen_Plastic_2847 had been fighting hair loss since 2019-2020 and was initially successful in regrowing his hair with finasteride. However, after contracting Covid three times back to back at the start of 2021, he started to lose his hair again. He found a new dermatologist who prescribed him oral minoxidil along with finasteride, but eventually decided it wasn't worth spending all the money to try and save his hair.

community Ejaculation & balding: NoFap has helped me stop my hair loss [case study]

40 upvotes 9 years ago

The user claims NoFap (abstaining from pornography, masturbation, and orgasm) helped stop their hair loss. Others argue that hair loss is primarily due to genetics and DHT, which can be managed with finasteride.