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research c-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

142 citations , March 2019 in “Molecules/Molecules online/Molecules annual”

This review discusses the role of the endocannabinoid system in skin health and disease, highlighting its potential for future research and applications, but reports no new experimental results.

Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts

research Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts

14 citations , March 2022 in “Journal of Biomedical Science”

In this study, Cyanidin 3-O-arabinoside was found to protect against DHT-induced dermal papilla cell senescence and mitochondrial dysfunction in androgenetic alopecia, restoring hair growth in mouse models.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.

research A randomized controlled clinical trial of recombinant interferon α‐2b in the treatment of acute post‐transfusion hepatitis C: A preliminary report

17 citations , January 1993 in “Journal of Gastroenterology and Hepatology”

This study found that recombinant IFN α-2b injections in patients with acute post-transfusion hepatitis C can suppress viral RNA and lead to normalization of serum ALT, though long-term prevention of chronicity remains unclear.

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community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

15 upvotes 2 years ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

737 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Don't take Dutasteride. Dutasteride destroyed my hairline. Dutasteride gave me cow tits. Dutasteride killed my family.

in Satire 40 upvotes 1 year ago

Dutasteride is humorously criticized for causing hairline damage and unwanted side effects. The conversation is satirical, with users joking about the effects of Dutasteride.

community PP405 gets its generic name - Suvomipic

287 upvotes 1 month ago

Suvomipic, previously known as PP405, is progressing to Phase 3 trials for hair loss treatment. Its effectiveness compared to existing treatments like Minoxidil and Finasteride is still uncertain.

community I give up on hoping for a cure

73 upvotes 2 months ago

The conversation is about disappointment in the lack of new hair loss cures, with discussions on treatments like finasteride, minoxidil, and hair transplants. Some users express hope for future advancements, while others debate the effectiveness and side effects of current treatments.

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learn Vitamin B12

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