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This study found that repeated cycles of wetting and blow-drying hair fibers can cause cracks in the hair cuticles, particularly among individuals who frequently blow-dry their hair.

This study found that mechanical damage from grooming and environmental factors contributes to crack formation and eventual breakage in African-American hair, highlighting the need for continuous care.

The authors reported a possible association between the use of etanercept and the development of trichorrhexis nodosa, a hair shaft disorder, in a patient without apparent external causes.

Hair fibers break by cuticle cell slipping, shape changing, cuticle fraying, and surface cracking when stretched under specific conditions.

In this case series, mesenchymal stem cell exosomes were reported to improve hair length, density, pigmentation, and cuticle layer recovery in three patients with acquired trichorrhexis nodosa, suggesting potential as a therapeutic approach for this hair condition.