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GlossaryCD8+ T cells (CTLs)

specialized immune cells that destroy infected or cancerous cells

CD8+ T cells, also known as cytotoxic T cells or killer T cells, are a type of white blood cell that plays a crucial role in the immune system. They are responsible for identifying and destroying infected or cancerous cells by recognizing specific antigens presented on the surface of these cells.

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research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations , September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research The Pathogenesis of Alopecia Areata

November 2015

Alopecia areata is an autoimmune disease affecting hair follicles and may harm heart health.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations , September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

research Rebound Effect Associated with JAK Inhibitor Use in the Treatment of Alopecia Areata

11 citations , December 2018 in “Journal of the European Academy of Dermatology and Venereology”

Stopping JAK inhibitor treatment for hair loss can lead to worse hair loss than before the treatment.

T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus

research T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus

8 citations , October 2016 in “Experimental dermatology”

Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.

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