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GlossaryCytotoxic T-Lymphocyte Antigen 4 (CTLA-4)

regulates immune response by inhibiting T cell activation

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) is a protein found on the surface of T cells, which are a type of immune cell. It acts as an "off switch" to help regulate the immune system by preventing it from attacking the body's own tissues. This protein is crucial in maintaining immune tolerance and preventing autoimmune diseases.

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Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

research Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

2 citations , December 2019 in “Al-ʻulūm al-ṣaydalāniyyaẗ”

The CTLA-4 gene change studied does not affect Polycystic Ovarian Syndrome in the women tested.

research Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

October 2019 in “Al Mustansiriyah Journal of Pharmaceutical Sciences”

The CTLA-4 gene polymorphism does not affect polycystic ovarian syndrome.

research Analysis of CTLA-4 Gene +49A/G and CT60 A/G Polymorphisms in Alopecia Areata Patients

August 2023 in “Sabuncuoglu Serefeddin Health Sciences”

CT60 polymorphism might increase the risk of Alopecia Areata.

research Panhypopituitarism Induced by CTLA-4 and PD-1/PD-L1 Inhibitor Immunotherapy

November 2022 in “Journal of the Endocrine Society”

Immunotherapy for cancer caused a patient to develop a condition affecting hormone production, requiring ongoing hormone replacement therapy.

research Tregs: Where We Are and What Comes Next?

130 citations , November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

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