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GlossaryCytotoxic T-Lymphocyte Antigen 4 (CTLA-4)

regulates immune response by inhibiting T cell activation

Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) is a protein found on the surface of T cells, which are a type of immune cell. It acts as an "off switch" to help regulate the immune system by preventing it from attacking the body's own tissues. This protein is crucial in maintaining immune tolerance and preventing autoimmune diseases.

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research Regulatory T Cells: The Many Faces of Foxp3

125 citations, September 2019 in “Journal of Clinical Immunology”

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

research Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors

87 citations, December 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

Cancer patients treated with immune checkpoint inhibitors may develop alopecia, but some hair regrowth is possible with treatment.

Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

research Studying Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

2 citations, December 2019 in “Al-ʻulūm al-ṣaydalāniyyaẗ”

The CTLA-4 gene change studied does not affect Polycystic Ovarian Syndrome in the women tested.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings

6 citations, December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

Alopecia areata involves complex immune and genetic factors, with potential treatment targets identified, but more research is needed.

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