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GlossaryCystatin M/E (CST6)

protein inhibiting enzymes that break down other proteins

Cystatin M/E, also known as CST6, is a protein that acts as an inhibitor of cysteine proteases, enzymes that break down proteins. It plays a crucial role in skin and hair follicle development by regulating the activity of these enzymes, ensuring proper cell growth and differentiation. Deficiencies or mutations in CST6 have been linked to certain skin disorders and may contribute to hair loss conditions like alopecia.

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research A Null Mutation in the Cystatin M/E Gene of Ichq Mice Causes Juvenile Lethality and Defects in Epidermal Cornification

66 citations, October 2002 in “Human molecular genetics online/Human molecular genetics”

A gene mutation in mice causes skin defects and early death.

Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

10 citations, November 2018 in “Genetics in medicine”

Lack of cystatin M/E causes thin hair and dry skin.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations, November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

research Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Not having enough cystatin M/E protein causes less hair growth and dry skin.

Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence

research Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence

77 citations, March 2021 in “Nature”

Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.

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