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GlossaryCancer Stem Cells (CSC)

small subset of tumor cells that can self-renew and differentiate

Cancer Stem Cells (CSCs) are a small subset of cells within a tumor that possess the ability to self-renew and differentiate into various cell types found in the cancer. These cells are thought to be responsible for tumor growth, metastasis, and recurrence after treatment, making them a critical target for cancer therapies.

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research Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer

124 citations, February 2018 in “Nature Reviews Genetics”

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

research Dormancy in the Stem Cell Niche

29 citations, March 2012 in “Stem Cell Research & Therapy”

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

research Exploring Pericyte and Cardiac Stem Cell Secretome Unveils New Tactics for Drug Discovery

26 citations, December 2016 in “Pharmacology & Therapeutics”

New drugs for heart disease may be developed from molecules secreted by stem cells.

research Epigenetic Regulation in Adult Stem Cells and Cancers

20 citations, January 2013 in “Cell & Bioscience”

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

research Understanding Cancer Cells of Origin in Cutaneous Tumors

1 citations, January 2016 in “Elsevier eBooks”

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

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