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research Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression

41 citations , September 2003 in “Journal of Investigative Dermatology”

Overexpression of COX-2 causes early hair loss in mice, but can be prevented with a COX-2 inhibitor.

research Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

113 citations , May 2002 in “PubMed”

Overexpressing COX-2 in mice skin reduces skin tumor development.

research Metabolic Pathways of Eicosanoids: Derivatives of Arachidonic Acid and Their Significance in Skin

January 2025 in “Cellular & Molecular Biology Letters”

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications

165 citations , September 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

research Clinical Snippets: Dermatology Studies on Sunburn, Hair Loss, and More

1 citations , March 2003 in “Journal of Investigative Dermatology”

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.

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community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

in Research/Science 3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 8 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community Has anyone had any real success combining oils such as peppermint, rosemary, castor, etc.?

in Question 8 upvotes 6 years ago

The conversation is about someone using minoxidil, low-dose aspirin, and LLLT for hair loss, finding microneedling painful, considering topical finasteride, and feeling frustrated enough to think about shaving their head. They are inquiring about the effectiveness of combining oils like peppermint, rosemary, and castor for hair loss treatment.

community Stop Using Salicylic acid on your face if using minoxidil for beard growth

in Product 20 upvotes 1 year ago

Salicylic acid can reduce the effectiveness of minoxidil for beard growth. Users discuss avoiding salicylic acid when using minoxidil.

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