62 citations
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February 2011 in “Expert review of dermatology” This review discusses the incidence, reversibility, and impact of chemotherapy-induced alopecia and concludes that scalp cooling is the most effective prevention method in most cases, though some questions remain.
53 citations
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June 1982 in “The BMJ” Cooling the scalp below 22°C before and during chemotherapy can help prevent hair loss.
27 citations
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June 2011 in “Journal of Advanced Nursing” The research observed that a penguin cap scalp cooling system may effectively reduce chemotherapy-induced alopecia, though its success varies due to individual characteristics and treatment regimens.
11 citations
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October 2020 in “PLoS ONE” This study found that scalp cooling markedly reduces cellular uptake of anthracycline drugs in human keratinocytes, partially explaining its protective effect against chemotherapy-induced cytotoxicity.
4 citations
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November 2000 in “Dermatologic surgery” This abstract does not provide any research findings or conclusions, as it appears to be journal subscription and navigation information rather than a study summary.